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The soluble form (GHBP) is made by phorbol ester-promoted proteolytic cleavage on the cell floor (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone linked to regulating postnatal overall body growth. On ligand binding, couples on the JAK2/STAT5 pathway. The soluble type (GHBP) functions for a reservoir of growth hormone in plasma and could be a modulator/inhibitor of GH signaling.
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